kev taw qhia
Gorelatide, tseem hu ua n-acetyl-serine - aspartic acid - proline - proline - (N-Acetyl-Ser-Asp-Lys-Pro), abbreviated li Ac-SDKP, yog ib qho endogenous tetrapeptide, nitrogen kawg acetylation, dav faib nyob rau hauv ntau cov ntaub so ntswg thiab cov kua dej hauv lub cev.Qhov no tetrapeptide yog tso tawm los ntawm prolyl oligopeptidase (POP), uas yog tshwm sim los ntawm nws precursor thymosin.Qhov concentration hauv cov ntshav feem ntau yog nyob ntawm nanomole nplai.
okinetics
Raws li kev tshawb fawb pharmacokinetic ntawm Gorelatide, tom qab txhaj tshuaj, Gorelatide sai sai degrades nrog ib nrab-lub neej ntawm tsuas yog 4 ~ 5min.Gorelatide yog tshem tawm ntawm tib neeg plasma los ntawm ob lub tswv yim:①Angiotensin-hloov enzyme (ACE) -guided hydrolysis;②Glomerular pom.Lub hydrolysis ntawm angiotensin converting enzyme (ACE) yog txoj hauv kev tseem ceeb ntawm gorelatide metabolism.
Kev ua si lom neeg
Gorelatide yog ib hom kev tswj hwm lub cev muaj zog nrog ntau yam kev ua haujlwm lom neeg.Nws tau tshaj tawm ua ntej tias Gorelatide tuaj yeem tiv thaiv kev nkag mus ntawm thawj hematopoietic qia hlwb mus rau theem S thiab ua rau lawv nyob ruaj khov hauv G0 theem, inhibiting kev ua haujlwm ntawm hematopoietic qia hlwb.Tom qab ntawd nws tau pom tias Gorelatide tuaj yeem txhim kho qhov muaj peev xwm rov ua dua tshiab los ntawm kev txhawb nqa cov hlab ntsha thiab ua kom lub qhov txhab zoo hauv cov kab mob vascularized epidermal grafts.Gorelatide tuaj yeem cuam tshuam qhov sib txawv ntawm cov pob txha pob txha qia hlwb txhawb nqa los ntawm MGM rau hauv macrophages, yog li ua lub luag haujlwm tiv thaiv.Gorelatide tsis ntev los no tau pom tias inhibit qhov kev loj hlob ntawm ntau lub hlwb.
siv
Raws li polypeptide organic teeb meem, Gorelatide tuaj yeem siv los ua cov khoom siv tshuaj.
Post lub sij hawm: Apr-26-2023