Lus Askiv: Omiganan
Lus Askiv: Omiganan
CAS Nr .: 204248-78-2
Cov mis mos molecular: C₉₀H₁₂₇N₂₇O₁₂
Molecular Luj: 1779.15
Sequence: ILRWPWWPWRRK-NH2
Cov tsos mob: dawb los yog tawm-dawb hmoov hmoov hmoov
Yuav ua li cas Omiganan ua:
Nws yog peptide me me heev thiab yog li nyuaj rau txheeb xyuas thiab sau npe rau proteolysis;Nws yog amidated ntawm C terminus los tiv thaiv proteolysis ntxiv thiab tshem tawm cov nqi tsis zoo ntawm pawg carboxyl.Nws yog amphiphilic thiab tuaj yeem cuam tshuam nrog cov cell membrane.Cell membrane yuav tsum yog ib qho ntawm lawv lub hom phiaj tseem ceeb.Nws yog ib qho polycation uas nyiam lawv cov kev sib cuam tshuam nrog cov kab mob tsis zoo thiab cov zomeric sab nrauv ntawm lipopolysaccharide (LPS) nrog cov kab mob mammalian es tsis yog peptidoglycan.Hauv cov kab mob, lub peev xwm ntawm daim nyias nyias kuj muaj qhov tsis zoo ntau dua li ntawm cov kab mob mammalian, uas tuaj yeem txhim kho cov tshuaj tua kab mob thiab hloov chaw.Qhov kawg qhov tseem ceeb yog qhov kev kho mob tsis zoo uas cov tshuaj tiv thaiv kab mob cytidine kuj muaj cov haujlwm ntawm erythrocytes, thaum Omiganan zoo li tsis tshua muaj hemolytic.Raws li tau hais los saum no, cov seem seem ntawm omiga-nan nyob ze ntawm txhua lub davhlau ya nyob twg, nyob deb ntawm thaj chaw hydrophobic ntawm peptide, thiab tag nrho cov nqi zoo ntawm peptide nce los ntawm 4+ rau 5+, uas tuaj yeem piav qhia los ntawm kev txo qis hemolysis. , vim tias cov kev hloov no tsis zoo rau cov tshuaj peptide zoo li cuam tshuam nrog zwitt-rionic mammalian daim nyias nyias.Qhov no yog corroborated los ntawm cov txiaj ntsig ntawm Staubitz thiab lwm tus, qhov chaw nruab nrab ntawm cov khoom siv tiv thaiv kab mob antiinflammatory cetin hauv omiganan cuam tshuam nrog kev ua si, qhov seem ntawm lub davhlau ya nyob twg zoo li kho qhov tshwj xeeb ntawm lub hom phiaj.
Omiganan yog siv rau:
Omiganan yog ib qho tshiab hluavtaws cationic antimicrobial peptide tam sim no nyob rau hauv kev txhim kho rau kev tiv thaiv kab mob ntsig txog catheter thiab kho pob txuv thiab rosacea.Hauv txoj kev tshawb no, peb tau soj ntsuam qhov ua tau zoo ntawm cov tshuaj pleev ib ce ntawm omiganan gel hauv ob daim tawv nqaij cog qauv (hauv vivo porcine daim tawv nqaij thiab hauv vivo guinea npua daim tawv nqaij).omiganan0 tau sim nyob rau hauv ib qho ex vivo porcine daim tawv nqaij colonization qauv 1 txog 2% ntawm tus neeg sawv cev gel pom tias muaj zog koob tshuaj tiv thaiv kab mob Gram-positive thiab Gram-negative kab mob thiab cov poov xab, nrog rau qhov siab tshaj plaws tshwm sim ntawm 1 thiab 2%.Tsis muaj qhov sib txawv tseem ceeb hauv kev ua haujlwm ntawm methicillin-resistant thiab susceptible Staphylococcus aureus, thiab kev ua yeeb yam tsis cuam tshuam los ntawm qhov loj ntawm cov khoom inoculated.Omiganan1% gel muaj cov tshuaj tiv thaiv kab mob sai, nrog rau 2.7log (10) txo qis hauv cov cheeb tsam ntawm Staphylococcus epidermolis / site ntawm 1 h thiab 5.2log (10) txo qis hauv flagella / site ntawm 24 teev tom qab thov.Lub zog muaj zog tiv thaiv kab mob thiab tshuaj tua kab mob ntawm Omiganan1% gel tau lees paub los ntawm lwm cov kev tshawb fawb hauv cov qauv ntses taub ntswg ntev ntawm daim tawv nqaij colonization.Hauv cov ntsiab lus, Omiganem gels tau pom tias muaj cov kab mob tua kab mob sai thiab cov kab mob bactericidal nrog rau qhov pom tseeb ntawm koob tshuaj ntawm cov kab mob dav dav.Cov txiaj ntsig no qhia ntxiv txog qhov muaj peev xwm ntawm cov tshuaj raws li cov tshuaj tua kab mob tshuaj tua kab mob.
Post lub sij hawm: Jun-27-2023