Tecosactideyog ib qho hluavtaws 24-peptide corticotropin analogue.Cov amino acid sequence yog zoo tib yam rau 24 amino acids ntawm cov amino-terminal ntawm ntuj corticotropin (tib neeg, bovine thiab porcine), thiab nws muaj tib lub physiological kev ua ub no raws li ntuj ACTH."Nws yog tus cwj pwm los ntawm qhov tsis muaj cov tshuaj tiv thaiv kab mob, feem ntau tsis muaj kev phiv loj, thiab tshwj xeeb tshaj yog rau cov neeg mob uas muaj kev fab tshuaj lossis tsis muaj txiaj ntsig rau ntuj porcine corticotropin."
"Nws induces adrenal hyperplasia, nkoos lub secretion ntawm adrenocortical hormones, tshwj xeeb tshaj yog (cortisol) thiab ib co mineralocorticoids xws li corticosterone, thiab kuj nkoos lub secretion ntawm androgens, tab sis nrog ib tug tsis muaj zog nyhuv.
Daim ntawv no piav qhia luv luv txog ticcotide thiab nws cov tshuaj pharmacological
Muaj me ntsis cuam tshuam rau aldosterone secretion.Ib nrab-lub neej yog 3 teev.Hauv xyoo 2008, FDA pom zoo Tecokotide los ntawm Novartis rau kev kuaj mob ntawm adrenal tsis txaus.Tam sim no nws tab tom kawm ntawm RandboudUniversity rau kev kho mob ntawm idiopathic membranous nephropathy.
Tag nrho cov kua theem synthesis yog cov txheej txheem synthesis ntawm ticacotide.Txoj kev no muaj ntau cov kauj ruam, ntev synthesis lub sij hawm, thiab yuav tsum tau kim catalysts thiab high-pressure cov cuab yeej, uas muaj qhov tsis zoo ntawm cov nqi siab, ntau impurities, kev ua haujlwm txaus ntshai, thiab tsis tshua muaj txiaj ntsig.Nws tau raug tshaj tawm tias kev sib xyaw ua ke ib los ntawm ib tus siv lub tswv yim Z-tiv thaiv, uas siv hydrogenation tshem tawm cov kev tiv thaiv ntawm txhua kauj ruam, muaj cov kauj ruam ntev, kev ua haujlwm tsis yooj yim, tus nqi siab thiab tsis tshua muaj txiaj ntsig.Serine yog nquag mus rau racemization vim ib-rau-ib coupling thaum lub sij hawm purification, uas yog nyuaj rau purify.
"Zoo li adrenocorticotropic hormone, ticcotide txhawb kev tso tawm ntawm cov tshuaj hormones cortical (tsuas yog cortisol) los ntawm adrenal cortex."Yog li ntawd, tsis muaj kev cuam tshuam rau cov neeg mob uas muaj mob hnyav adrenocortical dysfunction.
Ticocotide yog ib qho hluavtaws polypeptide uas muaj 24 amino acids.Nws zoo ib yam hauv cov qauv rau thawj mus rau 24th amino acids ntawm ACTH.Intravenous tswj kom ceev cov ntshav cortisol.Kev tso dej tas li yuav tsum tau siv los tswj cov ntshav cortisol concentration.Rau kev txhaj tshuaj intramuscular, ntshav cortisol mus txog qhov siab tshaj plaws ntawm 1h tom qab txhaj tshuaj.Tom qab ntawd, nce cortisol tuaj yeem tswj tau li ntawm 24 teev.
Post lub sij hawm: Lub Xya hli ntuj-11-2023