Txheej txheem cej luam thiab kev siv ntawm cerulein

Txheej txheem cej luam

Caerulein, tseem hu ua cerulein, yog daim tawv nqaij extract ntawm Australian qav HYlacaerulea muaj 10 amino acids.Nws yog ib qho decapeptide molecule muab los ntawm trifluoroacetate uas ua raws li cholecystokinin analogue ntawm pancreatic vesicular hlwb thiab tuaj yeem ua rau muaj ntau cov enzymes digestive thiab kua txiv pancreatic, uas ua rau mob pancreatitis.Cerutin tuaj yeem siv los kawm Nf-κb up-regulation proteins xws li intercellular adhesion molecule-1 (ICAM-1) kev mob ntsig txog yam xws li NADPH oxidase thiab Janus kinase mediated signal transduction.Nws tau ua tiav siv los tsim cov qauv ntawm tus mob pancreatitis hauv nas, nas, dev, thiab Syrian hamsters (AP).Intravenous kua yog qhov zoo tshaj plaws los ntawm kev txhaj tshuaj intravenous, dermal, lossis intraperitoneal txhaj.Nws yog dav siv nyob rau hauv kev soj ntsuam thwmsim ntawm mob edematous pancreatitis, thiab nyob rau hauv vitro thwmsim yog siv rau cell qauv.Tsis tas li ntawd, nws yog siv rau kev kuaj mob gallbladder.

Txheej txheem cej luam thiab kev siv ntawm cerulein

Cov lus qhia ntxaws

Qhov tsos: dawb hmoov

CAS Nr .: 17650-98-5

Tus Qauv Zauv: GT-F055

Sequence: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Cov mis mos molecular: C58H73N13O21S2

Molecular Luj: 1352.4

Solubility: Dissolved nyob rau hauv 50mM ammonium hydroxide ntawm ib tug concentration ntawm 1.0mg / ml

Daim ntawv thov

1. Nws yog dav siv nyob rau hauv cov qauv ntawm tus mob edematous pancreatitis nyob rau hauv kev sim tshuaj.

2. Daim ntawv thov rau cov qauv ntawm tes hauv vitro.

3. Siv rau kev kuaj mob gallbladder.

Txhawm rau tsim ib qho qauv rau kev kawm txog tus mob pancreatitis rau kev kawm ntawm cerulein (AP) cell biology, pathophysiological yam ntxwv thiab kev tshwm sim ntawm cov kab mob organic hauv tus mob pancreatitis.Ntxiv nrog rau kev tshawb xyuas cov kev hloov pauv hauv pulmonary ntawm tus kab mob AP, nws kuj tseem tuaj yeem qhia tau zoo txog kev cuam tshuam ntawm visceral endocrine xws li qib metabolin thiab CCK.Nws kuj tseem tuaj yeem siv los ntsuas kev kho mob thiab rov qab los ntawm cov ntaub so ntswg raug mob tom qab tshem tawm cov khoom phom sij.

5. Kev siv Caerulein cerulein (cerulein) thiab LPS los tsim cov qauv pancreatitis tuaj yeem ua rau muaj kev sib koom ua ke, cov qub tuaj yeem tsim cov pancreatic enzymes los rhuav tshem cov txiav, thiab tsis tu ncua ua kom cov kab mob inflammatory kom tso cov kab mob inflammatory.Tom qab ntawd, LPS cuam tshuam cov lus teb ib txwm ntawm cov neeg kho mob inflammatory, yog li tsim cov kab mob pancreatitis hauv zos raws li qhov tshwm sim ntawm qhov tshwm sim loj heev.

6. Cerulein tuaj yeem siv los tiv thaiv kab mob gallbladder, raum colic, thiab mob claudication tsis sib xws.Nws yog feem ntau suav hais tias yog ib qho endogenous kephalin antagonist.