Action mechanism
Enzymes yog cov proteins uas ua rau cov tshuaj tiv thaiv tshuaj.Lub enzyme cuam tshuam nrog lub substrate los hloov nws mus rau hauv cov khoom kawg.Inhibitors khi rau ib leeg los tiv thaiv lub substrate los ntawm kev nkag mus rau qhov chaw nquag ntawm cov enzyme thiab / lossis tiv thaiv cov enzyme los ntawm kev ua kom cov tshuaj tiv thaiv.Muaj ntau ntau hom inhibitors uas koom nrog: tsis yog tshwj xeeb, irreversible, thim rov qab - kev sib tw thiab tsis sib tw.Reversible inhibitors khi rau cov enzymes nrog kev sib cuam tshuam uas tsis yog-covalent (xws li, kev sib cuam tshuam hydrophobic, hydrogen thiab ionic bonds).Kev tswj tsis tau tshwj xeeb suav nrog thaum kawg denaturating ib feem ntawm cov protein ntawm cov enzyme thiab yog li zam tag nrho cov tshuaj tiv thaiv lub cev lossis tshuaj.Cov inhibitors tshwj xeeb ua rau ntawm ib qho enzyme.Cov tshuaj lom feem ntau ua raws li kev tswj hwm cov enzymes.Competitive inhibitors yog tag nrho cov tebchaw uas zoo ib yam li cov qauv tshuaj thiab molecular geometry ntawm cov tshuaj tiv thaiv substrate.Tus inhibitor tuaj yeem cuam tshuam nrog cov enzyme ntawm qhov chaw nquag, tab sis tsis muaj qhov tshwm sim tshwm sim.Noncompetitive inhibitors yog cov tshuaj uas cuam tshuam nrog enzymes tab sis feem ntau tsis cuam tshuam ntawm qhov chaw nquag.Lub hom phiaj ntawm qhov tsis sib tw inhibitor yog hloov cov duab ntawm cov enzyme, yog li cuam tshuam rau qhov chaw nquag, kom lub substrate tsis muaj peev xwm cuam tshuam nrog cov enzyme react.Non-competitive inhibitors feem ntau thim rov qab.Irreversible inhibitors tsim muaj zog covalent bonds nrog enzymes.Qee qhov inhibitors tuaj yeem ua rau lossis ib puag ncig ntawm qhov chaw nquag.
siv
Enzymes yog siv dav hauv kev lag luam hauv kev lag luam, xws li kev ntxuav tais diav, zaub mov thiab kev lag luam brewing.Proteases yog siv rau hauv "microbial" ntxuav hmoov txhawm rau txhawm rau txhawm rau cov proteins hauv av xws li ntshav thiab qe.Kev lag luam siv cov enzymes suav nrog tias lawv yog cov dej soluble, uas ua rau lawv nyuaj rau rov ua dua, thiab qee cov khoom kawg inhibit enzyme kev ua haujlwm (tso tawm tswv yim).
Cov tshuaj molecules, ntau cov tshuaj molecules yog ib qho enzyme inhibitors, thiab cov tshuaj enzyme inhibitors feem ntau tshwm sim los ntawm lawv qhov tshwj xeeb thiab cov nyhuv.Qhov tshwj xeeb thiab cov nyhuv qhia tau hais tias cov tshuaj muaj qhov cuam tshuam tsis zoo thiab tsis tshua muaj tshuaj lom.Enzyme inhibitors muaj nyob rau hauv cov xwm txheej thiab tau npaj thiab tsim ua ib feem me me ntawm cov tshuaj thiab biochemistry 6.
Cov tshuaj lom neeg feem ntau yog cov enzyme inhibitors uas tau hloov zuj zus los tiv thaiv ntoo lossis ntau yam tsiaj los ntawm cov tsiaj txhu.Cov co toxins no suav nrog ntau yam tshuaj lom ntau tshaj plaws puas tau pom.
Post lub sij hawm: Apr-25-2023