Cov tshuaj tiv thaiv kab mob peptides no yog Ameslikas muab los ntawm kev tiv thaiv kab mob, tsiaj txhu, amphibians, thiab lwm yam, thiab lawv feem ntau suav nrog plaub pawg:
1. cecropin yog Ameslikas tam sim no nyob rau hauv lub cev tiv thaiv kab mob ntawm Cecropiamoth, uas yog feem ntau pom nyob rau hauv lwm yam kab, thiab zoo xws li cov bactericidal peptides kuj muaj nyob rau hauv cov hnyuv npua.Lawv feem ntau tshwm sim los ntawm thaj tsam alkaline N-terminal uas muaj zog ua raws li qhov ntev hydrophobic fragment.
2. Xenopus antimicrobial peptides (magainin) yog muab los ntawm cov leeg thiab plab ntawm Qav.Cov qauv ntawm xenopus antimicrobial peptides kuj pom tias yog helical, tshwj xeeb tshaj yog nyob rau hauv ib puag ncig hydrophobic.Kev teeb tsa ntawm xenopus antipeptides hauv lipid txheej tau kawm los ntawm N-labeled solid-phase NMR.Raws li kev hloov tshuaj lom neeg ntawm acylamine resonance, cov helices ntawm xenopus antipeptides yog qhov sib npaug ntawm qhov chaw, thiab lawv tuaj yeem sib sau ua ke los ua ib lub tawb 13 hli nrog cov qauv helical ntawm 30 hli.
3. defensin Defense peptides yog muab los ntawm tib neeg polykaryotic neutrophil luav polymacrophages nrog tag nrho cov lobule nuclear thiab plab hnyuv hlwb ntawm cov tsiaj.Ib pawg ntawm cov tshuaj tiv thaiv kab mob peptides zoo ib yam li mammalian tiv thaiv peptides tau muab rho tawm los ntawm kab, hu ua "kab tiv thaiv peptides".Tsis zoo li mammalian tiv thaiv peptides, kab tiv thaiv peptides tsuas yog tawm tsam cov kab mob Gram-zoo.Txawm tias kab tiv thaiv peptides muaj rau Cys residues, tab sis txoj kev sib txuas ntawm disulfide sib txawv.Tus choj intramolecular disulfide khi hom tshuaj tua kab mob peptides muab rho tawm los ntawm Drosophila melanogast zoo ib yam li cov nroj tsuag tiv thaiv peptides.Nyob rau hauv cov xwm txheej siv lead ua, kev tiv thaiv peptides tau nthuav tawm ua dimers.
4.Tachyplesin yog muab los ntawm horseshoe crabs, hu ua horseshoecrab.Cov kev tshawb fawb configuration qhia tau hais tias nws txais yuav ib qho antiparallel B-folding configuration (3-8 txoj hauj lwm, 11-16 txoj hauj lwm), nyob rau hauv uasβ-lub kaum sab xis yog txuas rau ib leeg (8-11 txoj haujlwm), thiab ob txoj haujlwm disulfide yog tsim los ntawm 7 thiab 12 txoj haujlwm, thiab nruab nrab ntawm 3 thiab 16 txoj haujlwm.Nyob rau hauv cov qauv no, hydrophobic amino acid nyob rau ntawm ib sab ntawm lub dav hlau, thiab rau cationic residues tshwm nyob rau ntawm tus Tsov tus tw ntawm lub molecule, yog li cov qauv kuj biophilic.
Nws ua raws li hais tias yuav luag tag nrho cov tshuaj tua kab mob peptides yog cationic nyob rau hauv cov xwm, txawm tias lawv txawv nyob rau hauv ntev thiab qhov siab;Thaum kawg, txawm nyob rau hauv daim ntawv ntawm alpha-helical los yogβ-folding, cov qauv bitropic yog cov yam ntxwv.
Post lub sij hawm: Apr-20-2023