L-carnosine yog ib tug me me molecule nrog ib tug natural dipeptide L-zoo li tus qauv uas yog feem ntau pom nyob rau hauv cov xwm thiab yog tsim los ntawm natural dipeptide L-zoo li tus qauv feem ntau pom nyob rau hauv cov xwm.Ib tug dipeptide muaj xws li β-alanine thiab L-histidine.Carnosine muaj ntau yam cellular antioxidant, tiv thaiv kev laus thiab kev noj qab haus huv ntawm lub cev thiab cov teebmeem kev kho mob, xws li kub siab, kab mob plawv, senile cataract, ulcer recovery, anti-tumor, immune model test, anti-stress factors and so on.
Lub luag haujlwm ntawm
Carnosine yog carnosine pom los ntawm Lavxias tus kws tshawb fawb Gulevich ua ke nrog carnitine.Hauv tebchaws United Kingdom, Kaus Lim Kauslim, Russia, thiab lwm lub tebchaws Suav, kev tshawb fawb tau pom tias carnosine muaj peev xwm antioxidant thiab muaj txiaj ntsig zoo rau tib neeg.Carnosine tau pom tias tshem tawm cov pa oxygen reactive (ROS) tsim los ntawm ntau oxidation ntawm fatty acids nyob rau hauv cell membrane thaum oxidative kev nyuaj siab, nrog rau α-β unsaturated aldehydes.
Ntau qhov kev tshawb fawb tau pom tias N-acetylcarnosine muaj txiaj ntsig zoo hauv kev tiv thaiv thiab kho kab mob cataract.Ib qho ntawm cov kev tshawb fawb no tau pom tias carnosine ameliorated cataracts tshwm sim los ntawm crystalline opacities nyob rau hauv nas induced los ntawm raug rau guanidine.Txawm hais tias cov lus thov no txhawb nqa ntau qhov txiaj ntsig zoo rau lub qhov muag xws li kev kho carnotin rau cataracts, lawv muaj, txog rau hnub no, tsis tau txais kev txhawb nqa los ntawm cov zej zog kev kho mob tseem ceeb.Royal Orthopedics, piv txwv li, tau thov tias carnosine tsis muaj kev nyab xeeb lossis siv tau zoo hauv kev kho mob ntawm cov kab mob cataracts.
Raws li tsab ntawv tshaj tawm xyoo 2002, carnosine tuaj yeem txhim kho kev sib raug zoo hauv zej zog thiab nce cov lus siv los ntawm cov menyuam yaus uas muaj kev puas siab puas ntsws, tab sis kev txhim kho tau thov hauv txoj kev tshawb no kuj tuaj yeem los ntawm kev txhim kho, placebo, lossis lwm yam tsis tau sau rau hauv daim ntawv ntsuam xyuas no.
Txoj kev ntawm synthesis
Tam sim no, txoj kev tsim cov carnosine muaj qee qhov tsis txaus: vim qhov kev txwv ntawm cov tshuaj tiv thaiv sab, cov tshuaj tiv thaiv sab no tau ua nrog kev koom tes ntawm L-histidine imidazole nplhaib.L-histidine yuav tig tsawg kawg yog 0.8% hauv cov txheej txheem tshuaj tiv thaiv, txo cov khoom tawm los;Nyob rau tib lub sijhawm, nws yog ib qho nyuaj rau cais L-carnosine nrog cov ntshiab optical purity los ntawm cov teeb meem sib xyaw (nws txoj kev sib hloov, imidazole isomers, thiab lwm yam), cuam tshuam rau kev lag luam purity, vim tias cov khoom sib xyaw no muaj cov khoom zoo sib xws rau L-carnosine.Vim tias muaj cov khoom sib xyaw ua ke, qhov ua rau L-carnosine yog tshuaj lom, tsis yog thawj cov tshuaj dawb huv.
Txoj kev tshiab ntawm L-carnosine ntau lawm yog raws li nram no: phthalic anhydride reacts β-alanine nrog phthalic anhydride β-phthaloylalanine, chlorinated reagent chlorides phthaloyl-β-phthaloylalanine rau phthaloyl-alanine β-alanyl chloride;L-trialkylsilane tiv thaiv compound reacts nrog trialkylchlorosilane los yog hexahydroxysilane, reacts nrog phthalyl β-alanyl chloride condensation ntawm hydrochloride, tshem tawm cov pab pawg neeg tiv thaiv nrog anhydrous cawv, thiab synthetates hydrochloride nyob rau hauv alkaline tov kom tau cov intermediate synthesis khoom, hydrochloride, hydrochloride thiab hydrochloride. L-carnosine nyob rau hauv anhydrous cawv.Cov khoom no yog ib lub nplhaib imidazole ntawm L-tiv thaiv histidine kom tsis txhob muaj kev phiv los ntawm imidazole nplhaib ntawm L-histidine thiab lwm yam tshuaj, thiab tau txais cov ntshiab L-carnosine uas tsis tshua muaj tshwm sim thiab siab tag nrho cov txiaj ntsig thiab cov ntsiab lus.
Post lub sij hawm: Oct-24-2023