Penicillin yog lub ntiaj teb thawj cov tshuaj tua kab mob siv hauv kev kho mob.Tom qab xyoo ntawm txoj kev loj hlob, ntau thiab ntau cov tshuaj tua kab mob tau tshwm sim, tab sis qhov teeb meem ntawm kev siv tshuaj tiv thaiv los ntawm kev siv tshuaj tua kab mob tau maj mam ua qhov tseem ceeb.
Antimicrobial peptides raug suav hais tias muaj ntau daim ntawv thov kev cia siab vim tias lawv cov kab mob ua haujlwm siab, cov kab mob tua kab mob dav dav, ntau yam, xaiv ntau yam, thiab tsis tshua muaj kev hloov pauv hauv cov hom phiaj.Tam sim no, ntau cov tshuaj tiv thaiv kab mob peptides nyob rau hauv kev tshawb fawb theem, cov magainins (Xenopus laevis antimicrobial peptide) tau nkag mus rau Ⅲ kev sim tshuaj.
Cov txheej txheem ua haujlwm tau zoo
Antimicrobial peptides (amps) yog cov polypeptides yooj yim nrog lub cev hnyav ntawm 20000 thiab muaj cov tshuaj tua kab mob.Nruab nrab ntawm ~ 7000 thiab muaj li ntawm 20 mus rau 60 amino acid residues.Feem ntau ntawm cov active peptides no muaj cov yam ntxwv ntawm lub hauv paus muaj zog, kev ruaj ntseg kub, thiab dav-spectrum antibacterial.
Raws li lawv cov qauv, cov tshuaj tua kab mob peptides tuaj yeem faib ua plaub pawg: helical, ntawv, txuas ntxiv, thiab nplhaib.Qee cov tshuaj tua kab mob peptides muaj tag nrho ntawm ib qho helix lossis daim ntawv, thaum lwm tus muaj cov qauv ntau dua.
Cov txheej txheem feem ntau ntawm kev ua ntawm cov tshuaj tua kab mob peptides yog tias lawv muaj kev ua haujlwm ncaj qha tawm tsam cov kab mob ntawm tes.Nyob rau hauv luv luv, antimicrobial peptides cuam tshuam lub peev xwm ntawm cov kab mob daim nyias nyias, hloov membrane permeability, xau metabolites, thiab thaum kawg ua rau cov kab mob tuag.Cov xwm txheej ntawm cov tshuaj tua kab mob peptides pab txhim kho lawv lub peev xwm los cuam tshuam nrog cov kab mob ntawm tes.Feem ntau cov tshuaj tiv thaiv kab mob peptides muaj cov txiaj ntsig zoo thiab yog li hu ua cationic antimicrobial peptides.Kev sib cuam tshuam ntawm electrostatic ntawm cationic antimicrobial peptides thiab anionic bacterial membranes stabilizes qhov khi ntawm antimicrobial peptides rau cov kab mob hauv daim nyias nyias.
Muaj peev xwm kho tau
Lub peev xwm ntawm antimicrobial peptides ua los ntawm ntau lub tswv yim thiab cov kev sib txawv tsis yog tsuas yog ua kom cov tshuaj tiv thaiv kab mob xwb tab sis kuj txo cov propensity rau kev tiv thaiv.Ua los ntawm ntau txoj hauv kev, qhov ua tau ntawm cov kab mob kis tau ntau yam kev hloov pauv tib lub sijhawm tuaj yeem txo qis, muab cov tshuaj tua kab mob peptides muaj peev xwm tiv taus.Tsis tas li ntawd, vim muaj ntau cov tshuaj tiv thaiv kab mob peptides ua rau cov kab mob ntawm cov kab mob hauv cov kab mob, cov kab mob yuav tsum rov tsim kho cov qauv ntawm cov cell membrane kom hloov, thiab nws yuav siv sij hawm ntev rau ntau qhov kev hloov pauv.Nws muaj ntau yam hauv kev kho mob qog noj ntshav kom txo cov qog tsis kam thiab tshuaj tiv thaiv los ntawm kev siv ntau lub tshuab thiab cov neeg ua haujlwm sib txawv.
Lub zeem muag kho mob yog qhov zoo
Tsim cov tshuaj tiv thaiv kab mob tshiab kom tsis txhob muaj teeb meem tshuaj tiv thaiv kab mob tom ntej.Ib tug loj tus naj npawb ntawm cov tshuaj tua kab mob peptides tab tom mus kuaj mob thiab qhia tau tias muaj peev xwm kho mob.Ntau qhov haujlwm tseem yuav tau ua ntawm cov tshuaj tiv thaiv kab mob peptides ua cov tshuaj tua kab mob tshiab.Ntau cov tshuaj tiv thaiv kab mob peptides hauv kev sim tshuaj tsis tuaj yeem raug coj mus rau kev lag luam vim qhov kev sim tsis zoo lossis tsis muaj kev siv tau.Yog li ntawd, kev tshawb fawb ntxiv txog kev sib cuam tshuam ntawm peptide-based antimicrobials nrog cov tib neeg ib puag ncig yuav muaj txiaj ntsig los ntsuas qhov tseeb ntawm cov tshuaj no.
Tseeb tiag, ntau lub tebchaw hauv kev sim tshuaj tau dhau los ua qee yam kev hloov kho tshuaj los txhim kho lawv cov khoom siv tshuaj.Hauv cov txheej txheem, kev siv cov tsev qiv ntawv digital qib siab thiab txhim kho cov qauv software yuav ua kom zoo dua rau kev tshawb fawb thiab kev tsim cov tshuaj no.
Txawm hais tias kev tsim thiab kev loj hlob ntawm antimicrobial peptides yog ib qho tseem ceeb ua hauj lwm, peb yuav tsum siv zog los txwv qhov tsis kam ntawm cov tshuaj tua kab mob tshiab.Kev txhim kho txuas ntxiv ntawm ntau yam tshuaj tua kab mob thiab cov tshuaj tiv thaiv kab mob yuav pab txo qis kev cuam tshuam ntawm cov tshuaj tiv thaiv kab mob.Tsis tas li ntawd, thaum tus neeg saib xyuas cov kab mob tshiab tau muab tso rau hauv kev ua lag luam, kev soj ntsuam kom ntxaws thiab kev tswj hwm yuav tsum tau txwv tsis pub siv cov tshuaj tua kab mob kom ntau li ntau tau.
Post lub sij hawm: Jul-04-2023